Heart & Cardiovascular Health

Song, D., et al., Hydrogenrich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats. Mol Med Rep, 2018. 18(2): p. 1925-1938.

Matsuoka, H., et al., Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clin Exp Hypertens, 2018: p. 1-5

Feng, R., et al., Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats. Appl Biochem Biotechnol, 2018.

Chi, J., et al., Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats. Frontiers in Physiology, 2018. 9: p. 1026.

Chen, K., et al., Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett, 2018. 16(1): p. 167-178.

Zalesak, M., et al., Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention. Can J Physiol Pharmacol, 2017. 95(8): p. 888-893.

Yang, J., et al., Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats. Mol Med Rep, 2017. 16(2): p. 1771-1778.

Tamura, T., et al., Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial. Trials, 2017. 18(1): p. 488.

Ridwan, R.D., W.S. Juliastuti, and R.D. Setijanto, Effect of electrolyzed reduced water on Wistar rats with chronic periodontitis on malondialdehyde levels. Dental Journal (Majalah Kedokteran Gigi), 2017. 50(1): p. 10-13.

Katsumata, Y., et al., The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction- First Pilot Study in Humans. Circ J, 2017.

Gao, Y., et al., Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy. Cell Physiol Biochem, 2017. 43(4): p. 1503-1514.

Gao, Y., et al., Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats. Neurosci Lett, 2017. 640: p. 29-36.

Chen, O., et al., High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway. Sci Rep, 2017. 7(1): p. 14871.

Zhang, Y., et al., Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways. Front Pharmacol, 2016. 7: p. 392.

Wang, P., et al., Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock, 2016. 46(3): p. 312-8.

Gao, Y., et al., Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis. Mediators Inflamm, 2016. 2016: p. 1320365.

Zhang, G., et al., Pharmacological postconditioning with lactic Acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats. Sci Rep, 2015. 5: p. 9858.

Yu, Y., et al., Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin. Genet Mol Res, 2015. 14(2): p. 6202-12.

Wu, F., et al., Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice. Cardiovasc Pathol, 2015. 24(5): p. 294-303.

Song, G., et al., Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice. Free Radic Biol Med, 2015. 87: p. 58-68.

Song, G., et al., Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. J Clin Endocrinol Metab, 2015. 100(7): p. 2724-33.

Jing, L., et al., Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. Heart Lung Circ, 2015. 24(6): p. 602-10.

Chen, H., et al., Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway. Int Immunopharmacol, 2015. 28(1): p. 643-54.

Xie, Q., et al., Hydrogen gas protects against serum and glucose deprivation induced myocardial injury in H9c2 cells through activation of the NFE2 related factor 2/heme oxygenase 1 signaling pathway. Mol Med Rep, 2014. 10(2): p. 1143-9.

Wu, S., et al., Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. Pharmazie, 2014. 69(8): p. 633-6.

Sakai, T., et al., Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag, 2014. 10: p. 591-7.

Jing, L., et al., Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. Heart Lung Circ, 2014.

Huo, T.T., et al., Hydrogen-Rich Saline Improves Survival and Neurological Outcome after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats. Anesth Analg, 2014.

Hayashida, K., et al., Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest, Independent of Targeted Temperature Management. Circulation, 2014.

Drabek, T. and P.M. Kochanek, Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2. Circulation, 2014. 130(24): p. 2133-5.

Shinbo, T., et al., Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Physiol Heart Circ Physiol, 2013. 305(4): p. H542-50.

Nagatani, K., et al., The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion. Brain Edema XV Acta Neurochirurgica Supplement 2013.

Fujii, Y., et al., Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model. Artif Organs, 2013. 37(2): p. 136-41.

Yoshida, A., et al., H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs. Cardiovasc Drugs Ther, 2012. 26(3): p. 217-26.

Sun, Q., et al., Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res, 2012. 94(1): p. 144-53.

Sakai, K., et al., Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.Scandinavian Cardiovascular Journal, 2012. 46(3): p. 183-9.

Qin, Z.X., et al., Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway. Atherosclerosis, 2012. 220(2): p. 343-50.

Noda, K., et al., Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int, 2012. 25(12): p. 1213-22.

Hayashida, K., et al., H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc, 2012. 1(5): p. e003459.

Kasuyama, K., et al., Hydrogen-rich water attenuates experimental periodontitis in a rat model. J Clin Periodontol, 2011. 38(12): p. 1085-90.

Hayashi, T., et al., Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. American Journal of Physiology – Heart and Circulatory Physiology, 2011. 301(3): p. H1062-9.